IL-17AF

IL-17A and IL-17F are well-characterized homodimeric cytokines secreted by T helper 17 (TH17) cells, γδ T cells, and several subsets of innate lymphoid cells. Somewhat less appreciated is that IL-17A and IL-17F subunits can also form the heterodimer IL-17AF. Together, these three dimers signal through the IL-17RA/IL-17RC receptor complex to mediate immune responses at mucosal interfaces and are found at lesion sites in inflammatory bowel disease, asthma, atopic dermatitis and rheumatoid arthritis. IL-17AF functions are believed to be similar to both IL-17A and IL-17F with autoimmunity pathology and neutrophil recruitment and immunity to extracellular pathogens. Please review IL-17A and IL-17F for additional information.

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Name	Clone	Application	Cat. No.	Reg.
Human IL-17AF Platinum ELISA		ELISA	BMS2082*	RUO
Human IL-17AF (heterodimer) ELISA Ready-SET-Go!®		ELISA	88-7117	RUO
Human IL-17AF FlowCytomix Simplex		Multiplex	BMS82082FF*	RUO
Human IL-17AF Recombinant Protein		ELISA, FA	14-8178	RUO
Human IL-17AF Recombinant Protein Carrier-Free		ELISA, FA	34-8178	RUO
Human IL-17AF Single-Use ELISA RSG Standard		ELISA	39-8178	RUO
Anti-Human IL-17AF eFluor® 450	20LJS09	FC	48-9179	RUO
Anti-Human IL-17AF FITC	20LJS09	FC	11-9179	RUO
Anti-Human IL-17AF PE	20LJS09	FC	12-9179	RUO

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents