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IL-17A

Alias: Interleukin-17A, CTLA-8, IL-17

Interleukin-17A (IL-17A) is the prototypic member of the IL-17 family of cytokines. IL-17A plays a critical role in host defense and inflammation. IL-17A expression is most often associated with the T helper 17 (TH17) subset of CD4+ T cells, but has also been observed in CD8+ T cells, neutrophils, and γδ T cells upon stimulation with IL-1 and IL-23. IL-17A is most similarly related to IL-17F with which it shares 50% sequence homology. Both IL-17A and IL-17F exist as either biologically active homodimers (IL-17AA and IL-17FF) or biologically active heterodimers (IL-17AF). All three protein complexes are currently believed to signal through the same receptor complex (IL-17R) composed of the subunits IL-17RA and IL-17RC (IL-17RL), though they appear to have different biological functions. One of the principle IL-17 functions appears to be the regulation of local tissue inflammation via the coordinated expression of various cytokines and chemokines that include IL-1, IL-6, IL-8, GM-CSF, G-CSF, TNF, CXCL1, MCP-1, MIP-2, MCP-3, and MIP-3α. Upon ligand/receptor interaction, IL-17A induces these inflammatory cytokine production in epithelial cells, endothelial cells, and fibroblasts through the NFκB and MAPK family pathways that results in the activation of many of the AP-1 proteins. IL-17 has become an important target for drug discovery for the treatment of various forms of autoimmunity and inflammatory diseases such as asthma, rheumatoid arthritis, multiple sclerosis, psoriasis, transplant rejection, and inflammatory bowel disease (IBD).

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

ProcartaPlex Human Essential Panel 2 (4 plex)

Multiplex EPX040-10008 RUO

ProcartaPlex Mouse Essential Panel 2 (8 plex)

Multiplex EPX080-20832 RUO

eZKine™ 4-Color Compensation Control Kit

FC 8822-6856 RUO

eZKine™ Th1/Th17 Whole Blood Intracellular Cytokine Kit

FC 8822-6850 RUO

eZKine™ Th17/Th22 Whole Blood Intracellular Cytokine Kit

FC 8822-6853 RUO

ProcartaPlex Human High Sensitivity Panel (9 plex)

Multiplex EPXS090-12199 RUO

Anti-Mouse/Rat IL-17A Alexa Fluor® 488

eBio17B7 FC, IHC 53-7177 RUO

Anti-Mouse/Rat IL-17A APC

eBio17B7 FC 17-7177 RUO

Anti-Mouse/Rat IL-17A Biotin

eBio17B7 ELISA, IHC 13-7177 RUO

Anti-Mouse/Rat IL-17A eFluor® 660

eBio17B7 FC, IHC 50-7177 RUO

Anti-Mouse/Rat IL-17A eFluor® 450

eBio17B7 FC 48-7177 RUO

Anti-Mouse/Rat IL-17A eFluor® 506

eBio17B7 FC 69-7177 RUO

Anti-Mouse/Rat IL-17A FITC

eBio17B7 FC, IHC 11-7177 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents