Alias: Interleukin-16, Lymphocyte chemoattractant factor (LCF
IL-16 is a cytokine that induces CD4+ T cell chemotaxis and activates monocytes, mast cells, dendritic cells, and eosinophils. IL-16 is produced by T lymphocytes, mast cells, dendritic cells, eosinophils, epithelial cells, and fibroblasts as a native pro-IL-16 that is cleaved by caspase-3 to produce a protein where the C- and N-termini function as a cytokine and cell cycle regulator, respectively. The cleaved monomers can associate to form a homotetramer that possess high cytokine activity. This cytokine also induces the expression of IL-2R (CD25) and MHC class II molecules on CD4+ T cells, indicating a role in immune-mediated and autoimmune diseases. IL-16 interacts directly with CD4 and has potential therapeutic use in treating HIV infection.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents