IL-15
IL-15 is a pro-inflammatory cytokine that plays a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential for the proliferation and differentiation of NK cells and CD8 T-cells. The receptor for IL-15 is a high affinity heterotrimeric receptor composed of IL-15Rα and 2 the β and γ subunits of IL-2R (CD25). IL-15 signals via the JAK/STAT pathways. Despite the expression of IL-15 mRNA in many cell types, secreted mouse IL-15 protein is rarely detectable in biological samples. Recent research suggests that mouse IL-15 is retained inside the cell and is only secreted in complex with its unique receptor, IL-15Rα. Human IL-15 mRNA is found in a wide variety of cell types that includes PBMC, placenta, skeletal muscle, kidney, lung, liver, and heart, though it is produced most abundantly by epithelial cells and monocytes. Functionally, IL-15 shares many biological properties with IL-2 that includes the stimulation of CTLL proliferation, in vitro generation of alloantigen-specific cytotoxic T cells and non-antigen specific lymphokine activated killer (LAK) cells, and upregulate the expression of IL-17RA by CD8+ T cells.
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| Name | Clone | Application | Cat. No. | Reg. | |
|---|---|---|---|---|---|
ProcartaPlex Human Cytokine Panel 1B (25 plex) |
Multiplex | EPX250-12166 | RUO | ||
ProcartaPlex Human Cytokine Panel 1C (7 plex) |
Multiplex | EPX070-10010 | RUO | ||
ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex) |
Multiplex | EPX340-12167 | RUO | ||
Anti-Mouse IL-15 Functional Grade Purified |
AIO.3 | FA | 16-7154 | RUO | |
Anti-Human IL-15 Functional Grade Purified |
ct2nu | FA | 16-0157 | RUO | |
Human IL-15 ELISA Ready-SET-Go!® |
ELISA | 88-7158 | RUO | ||
Anti-Mouse IL-15 Purified |
Polyclonal | WB | 14-7151 | RUO | |
ProcartaPlex Human IL-15 Simplex |
Multiplex | EPX010-12089 | RUO | ||
Recombinant Human IL-15 |
BMS319* | RUO | |||
Mouse IL-15 Recombinant Protein |
FA | 14-8153 | RUO | ||
Human IL-15 Recombinant Protein |
FA | 14-8159 | RUO | ||
Mouse IL-15 Recombinant Protein Carrier-Free |
FA | 34-8153 | RUO | ||
Human IL-15 Recombinant Protein Carrier-Free |
FA | 34-8159 | RUO | ||
Mouse IL-15 Single-Use ELISA RSG Standard |
ELISA | 39-8151 | RUO |
* = Please click on product link to see all available sizes and pricing.
FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents
