IL-15 is a pro-inflammatory cytokine that plays a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential for the proliferation and differentiation of NK cells and CD8 T-cells. The receptor for IL-15 is a high affinity heterotrimeric receptor composed of IL-15Rα and 2 the β and γ subunits of IL-2R (CD25). IL-15 signals via the JAK/STAT pathways. Despite the expression of IL-15 mRNA in many cell types, secreted mouse IL-15 protein is rarely detectable in biological samples. Recent research suggests that mouse IL-15 is retained inside the cell and is only secreted in complex with its unique receptor, IL-15Rα. Human IL-15 mRNA is found in a wide variety of cell types that includes PBMC, placenta, skeletal muscle, kidney, lung, liver, and heart, though it is produced most abundantly by epithelial cells and monocytes. Functionally, IL-15 shares many biological properties with IL-2 that includes the stimulation of CTLL proliferation, in vitro generation of alloantigen-specific cytotoxic T cells and non-antigen specific lymphokine activated killer (LAK) cells, and upregulate the expression of IL-17RA by CD8+ T cells.
Unless indicated otherwise, all products are For Research Use Only. Not for use in diagnostic or therapeutic procedures. Not for further distribution without written consent. Not all products available in all regions.