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IL-15

IL-15 is a pro-inflammatory cytokine that plays a role in the activation of neutrophils, dendritic cells, and macrophages, and is essential for the proliferation and differentiation of NK cells and CD8 T-cells. The receptor for IL-15 is a high affinity heterotrimeric receptor composed of IL-15Rα and 2 the β and γ subunits of IL-2R (CD25). IL-15 signals via the JAK/STAT pathways. Despite the expression of IL-15 mRNA in many cell types, secreted mouse IL-15 protein is rarely detectable in biological samples. Recent research suggests that mouse IL-15 is retained inside the cell and is only secreted in complex with its unique receptor, IL-15Rα. Human IL-15 mRNA is found in a wide variety of cell types that includes PBMC, placenta, skeletal muscle, kidney, lung, liver, and heart, though it is produced most abundantly by epithelial cells and monocytes. Functionally, IL-15 shares many biological properties with IL-2 that includes the stimulation of CTLL proliferation, in vitro generation of alloantigen-specific cytotoxic T cells and non-antigen specific lymphokine activated killer (LAK) cells, and upregulate the expression of IL-17RA by CD8+ T cells.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine 1C & Chemokine Panel 1 (16 plex)

Multiplex EPX160-12176 RUO

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Human Cytokine Panel 1C (7 plex)

Multiplex EPX070-10010 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex NHP Cytokine Panel 1b (6 plex)

Multiplex EPX060-40042 RUO

Anti-Mouse IL-15 Functional Grade Purified

AIO.3 FA 16-7154 RUO

Anti-Human IL-15 Functional Grade Purified

ct2nu FA 16-0157 RUO

Human IL-15 ELISA Ready-SET-Go! (2nd Generation)

ELISA 88-7620 RUO

Human IL-15 ELISA Ready-SET-Go!® (Discontinued. See replacement item 88-7620.)

ELISA 88-7158 RUO

Human IL-15 Platinum ELISA

ELISA BMS2106* RUO

Platinum ProcartaPlex Human IL-15 Simplex

Multiplex EPXP010-12089 RUO

ProcartaPlex NHP IL-15 Simplex

Multiplex EPX01A-42089 RUO

ProcartaPlex Human IL-15 Simplex

Multiplex EPX01A-12089 RUO

Recombinant Human IL-15

BMS319* RUO

Human IL-15 Recombinant Protein

FA 14-8159 RUO

Mouse IL-15 Recombinant Protein

FA 14-8153 RUO

Mouse IL-15 Recombinant Protein Carrier-Free

FA 34-8153 RUO

Human IL-15 Recombinant Protein Carrier-Free

FA 34-8159 RUO

ProcartaPlex Mouse IL-15/IL-15R Simplex

Multiplex EPX01A-26023 RUO

ProcartaPlex Human Myokine Panel (8 plex)

Multiplex EPX080-12186 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents