IL-12

Alias: Interleukin-12

IL-12, with STAT4 and T-bet, promotes differentiation into TH1 cells that produce IFNγ. The Interleukin-12 (IL-12) family of cytokines, which includes IL-12, IL-23, IL-27, and IL-35, are important mediators of inflammatory disease. Each member is a heterodimeric complex composed of two subunits whose expression is regulated independently. The founding member, IL-12 (also known as IL-12p70), consists of the heterodimer of p35 and p40. Moreover, studies have demonstrated that homodimers and monomers of the p40 subunit also exist (known as IL-12p40) and may act as antagonists of IL-12 function. IL-23 is composed of the heterodimer p40 and p19, which is homologous to p35. IL-27 is a heterodimeric cytokine consisting of Epstein-Barr virus-induced gene 3 (EBI3) and p28, which are related to p40 and p35, respectively. The most recently identified member of this family, IL-35, is composed of p35 and EBI3. As inducers of IFNγ production, IL-12, IL-23, and IL-27 play critical roles in regulating the inflammatory response. Moreover, each is involved in mediating T cell-dependent immunity. For example, IL-12 and IL-27 are involved in T helper 1 (TH1) differentiation, while IL-23 is critical for TH17 survival and expansion.

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23 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

Anti-Human IL-12 Purified

B-T21 (BT21) ELISA 14-7128 RUO

anti-human IL-12

B-T21 FA BMS152* RUO

Anti-Human IL-12 p70 Functional Grade Purified

20C2 ELISA, IHC, FA, WB 16-8126 RUO

Anti-Human IL-12 p35 eFluor® 660

SNKY35 FC 50-7359 RUO

ProcartaPlex Human IL-12p40 Simplex

Multiplex EPX010-12090 RUO

Human IL-12p70 High Sensitivity ELISA

ELISA BMS238HS* RUO

Human IL-12 (p70) Platinum ELISA

ELISA BMS238* RUO

Human IL-12 (p70) Platinum ELISA

ELISA BMS238CE* CE

Human IL-12 p70 ELISA Ready-SET-Go!®

ELISA 88-7126 RUO

Human IL-12 p70 Recombinant Protein

ELISA, FA 14-8129 RUO

Human IL-12 p70 Recombinant Protein Carrier-Free

ELISA, FA 34-8129 RUO

Human IL-12 p70 Single-Use ELISA RSG Standard

ELISA 39-8129 RUO

ProcartaPlex Human IL-12p70 Simplex

Multiplex EPX010-10238 RUO

ProcartaPlex Human Inflammation Panel (20 plex)

Multiplex EPX200-12185 RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

ProcartaPlex Human Th1/Th2 Cytokine Panel (11 plex)

Multiplex EPX110-10810 RUO

ProcartaPlex Human Essential Th1/Th2 Cytokine Panel (6 plex)

Multiplex EPX060-10009 RUO

ProcartaPlex Human Th1/Th2 & Chemokine Panel 1 (20plex)

Multiplex EPX200-12173 RUO

ProcartaPlex Human Th1/Th2 & Cytokine Panel 1C (18plex)

Multiplex EPX180-12172 RUO

ProcartaPlex Human Th1/Th2/Th9/Th17/Th22/Treg Cytokine Panel (18 plex)

Multiplex EPX180-12165 RUO

23 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents