Alias: Interleukin-12

IL-12, with STAT4 and T-bet, promotes differentiation into TH1 cells that produce IFNγ. The Interleukin-12 (IL-12) family of cytokines, which includes IL-12, IL-23, IL-27, and IL-35, are important mediators of inflammatory disease. Each member is a heterodimeric complex composed of two subunits whose expression is regulated independently. The founding member, IL-12 (also known as IL-12p70), consists of the heterodimer of p35 and p40. Moreover, studies have demonstrated that homodimers and monomers of the p40 subunit also exist (known as IL-12p40) and may act as antagonists of IL-12 function. IL-23 is composed of the heterodimer p40 and p19, which is homologous to p35. IL-27 is a heterodimeric cytokine consisting of Epstein-Barr virus-induced gene 3 (EBI3) and p28, which are related to p40 and p35, respectively. The most recently identified member of this family, IL-35, is composed of p35 and EBI3. As inducers of IFNγ production, IL-12, IL-23, and IL-27 play critical roles in regulating the inflammatory response. Moreover, each is involved in mediating T cell-dependent immunity. For example, IL-12 and IL-27 are involved in T helper 1 (TH1) differentiation, while IL-23 is critical for TH17 survival and expansion.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor 1A Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

Anti-Human IL-12 Purified

B-T21 (BT21) ELISA 14-7128 RUO

anti-human IL-12

B-T21 FA BMS152* RUO

Anti-Human IL-12 p70 Functional Grade Purified

20C2 ELISA, IHC, FA, WB 16-8126 RUO

Anti-Human IL-12 p35 eFluor® 660

SNKY35 FC 50-7359 RUO

ProcartaPlex Human IL-12/IL-23p40 Simplex

Multiplex EPX01A-12090 RUO

Human IL-12p70 High Sensitivity ELISA


Human IL-12 (p70) Platinum ELISA


Human IL-12 (p70) Platinum ELISA


Human IL-12 p70 ELISA Ready-SET-Go!®

ELISA 88-7126 RUO

Human IL-12 p70 Recombinant Protein

ELISA, FA 14-8129 RUO

Human IL-12 p70 Recombinant Protein Carrier-Free

ELISA, FA 34-8129 RUO

Human IL-12 p70 Single-Use ELISA RSG Standard

ELISA 39-8129 RUO

ProcartaPlex Human High Sensitivity IL-12p70 Simplex

Multiplex EPXS010-10238 RUO

Platinum ProcartaPlex IL-12p70 Simplex

Multiplex EPXP010-10238 RUO

ProcartaPlex Human IL-12p70 Simplex

Multiplex EPX01A-10238 RUO

ProcartaPlex Human Inflammation Panel (20 plex)

Multiplex EPX200-12185 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human Panel 2 (13 plex)

Multiplex EPXP130-10100 RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

ProcartaPlex Human Th1/Th2 Cytokine Panel (11 plex)

Multiplex EPX110-10810 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents