IL-12

Alias: Interleukin-12

IL-12, with STAT4 and T-bet, promotes differentiation into TH1 cells that produce IFNγ. The Interleukin-12 (IL-12) family of cytokines, which includes IL-12, IL-23, IL-27, and IL-35, are important mediators of inflammatory disease. Each member is a heterodimeric complex composed of two subunits whose expression is regulated independently. The founding member, IL-12 (also known as IL-12p70), consists of the heterodimer of p35 and p40. Moreover, studies have demonstrated that homodimers and monomers of the p40 subunit also exist (known as IL-12p40) and may act as antagonists of IL-12 function. IL-23 is composed of the heterodimer p40 and p19, which is homologous to p35. IL-27 is a heterodimeric cytokine consisting of Epstein-Barr virus-induced gene 3 (EBI3) and p28, which are related to p40 and p35, respectively. The most recently identified member of this family, IL-35, is composed of p35 and EBI3. As inducers of IFNγ production, IL-12, IL-23, and IL-27 play critical roles in regulating the inflammatory response. Moreover, each is involved in mediating T cell-dependent immunity. For example, IL-12 and IL-27 are involved in T helper 1 (TH1) differentiation, while IL-23 is critical for TH17 survival and expansion.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Porcine Cytokine & Chemokine Panel 1 (9 plex)

Multiplex EPX090-60829 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex Canine Cytokine/Chemokine/Growth Factor Panel 1 (11 plex)

Multiplex EPX110-50511 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

Anti-Human IL-12 Purified

B-T21 (BT21) ELISA 14-7128 RUO

anti-human IL-12

B-T21 FA BMS152* RUO

Anti-Mouse IL-12 p35 Purified

C18.2 ELISA, FA 14-7122 RUO

Mouse IL-12 Platinum ELISA

ELISA BMS616* RUO

Anti-Human IL-12 p70 Functional Grade Purified

20C2 ELISA, IHC, FA, WB 16-8126 RUO

Anti-Mouse IL-12 p35 Functional Grade Purified

MMp35A1.6 (A1.6) FA 16-7360 RUO

Anti-Human IL-12 p35 eFluor® 660

SNKY35 FC 50-7359 RUO

ProcartaPlex Canine IL-12/IL-23 p40 Simplex

Multiplex EPX010-50503 RUO

ProcartaPlex Human IL-12p40 Simplex

Multiplex EPX010-12090 RUO

ProcartaPlex NHP IL-12p40 Simplex

Multiplex EPX010-42090 RUO

Mouse IL-12 p40 monomer Single-Use ELISA RSG Standard

ELISA 39-8122 RUO

Human IL-12p70 High Sensitivity ELISA

ELISA BMS238HS* RUO

Human IL-12 (p70) Platinum ELISA

ELISA BMS238* RUO

Monkey IL-12 (p70) Platinum ELISA

ELISA BMS646* RUO

Mouse IL-12 p70 Platinum ELISA

ELISA BMS6004* RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents