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IL-11

Alias: Interleukin-11, Adipogenesis inhibitory factor, AGIF

IL-11 is a member of the IL-6 family of cytokines. It is a pleiotropic cytokine that has been shown to have broad effects on many cell types. IL-11 is produced by various cell types that include epithelial, endothelial, keratinocytes, stromal, neuronal, bone marrow stromal cells, fibroblasts, osteoclasts, and other stromal cells. IL-11 signals through a heterodimeric receptor consisting of a gp130 subunit, shared by several other cytokines, and an IL-11Rα subunit unique to IL-11. IL-11 exhibits pleiotropic effects on various cell types as it acts synergistically with other growth factors such as IL-3, SCF, and IL-4 to promote the development of cells from several hematopoetic lineages and also plays a role in the regulation of osteoclast differentiation and maturation. IL-11 also protects against cell death and inhibit inflammation at sites of tissue injury and has been implicated in TH2-mediated sensitization and inflammation in asthma.