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IL-1 beta

Alias: IL-1β, Interleukin-1 beta, IL1F2, Catabolin

IL-1β is a pro-inflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized in response to inflammatory stimuli as an inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1β into the active protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. IL-1β signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1α. These cytokines play important roles in innate host defense by triggering the production of other pro-inflammatory cytokines in target cells and initiating acute-phase responses. Their activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1β have been associated with multiple inflammatory related disorders including type 2 diabetes, cardiovascular disease, rheumatoid arthritis, gout, and several rare auto-inflammatory diseases.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Porcine Cytokine & Chemokine Panel 1 (9 plex)

Multiplex EPX090-60829 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

ProcartaPlex Human Essential Panel 2 (4 plex)

Multiplex EPX040-10008 RUO

ProcartaPlex Mouse Essential Panel 2 (8 plex)

Multiplex EPX080-20832 RUO

ProcartaPlex Human High Sensitivity Panel (9 plex)

Multiplex EPXS090-12199 RUO

Mouse IL-1 alpha ELISA Ready-SET-Go!

ELISA ELISA 88-5019 RUO

anti-human IL-1beta/FITC

B-A15 FC BMS127FI* RUO

anti-human IL-1beta

B-A15 FA BMS127* RUO

Anti-Mouse/Rat IL-1 beta Functional Grade Purified

B122 ELISA, FA 16-7012 RUO

Anti-Mouse/Rat IL-1 beta Purified

B122 ELISA, FA 14-7012 RUO

Anti-Human IL-1 beta Functional Grade Purified

CRM56 ELISA, FA 16-7018 RUO

Human IL-1beta High Sensitivity ELISA

ELISA BMS224HS* RUO

Human IL-1 beta Instant ELISA

ELISA BMS224INST* RUO

Mouse IL-1beta Instant ELISA

ELISA BMS6002INST* RUO

Human IL-1beta Instant ELISA

ELISA BMS224INSTCE* CE

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents