Alias: Interferon omega, IFNω
IFNω is a major component of human leukocyte IFN with a contribution to its total antiviral activity estimated to be in the range of 10 -15 %, though the IFNω gene is not expressed in unstimulated cells. Viral infection results in expression of the gene, followed by its binding to the cell membrane receptor type I. IFNω anti-viral activity has been observed in various systems. Furthermore, IFNω has also been shown in correlation in human carcinoma cell lines. Immunomodulatory effects can as well be ascribed to IFNω. The physiological role of IFNω is currently not known. It is thought that the therapeutically administeration of IFNω may cause measurable serum concentrations in the corresponding patients and that the monitoring of these IFNω serum levels provides an important tool in therapy.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents