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IFN alpha

Alias: Interferon alpha, IFNα

IFNα is a type I interferon that is a pleiotropic agent that functions in anti-viral, anti-proliferative, and immunomodulatory activities. Type I IFNs inhibit growth-promoting cytokines, induce apoptosis, and inhibit cell proliferation. As such IFNα has a known role as an anti-neoplastic agent in the treatment of several cancers. In humans, the IFNα family comprises more than 20 genes and pseudogenes giving rise to 15 different functional gene products. IFNα is produced by monocytes, macrophages, lymphoblastoid cells, fibroblasts, and a number of different cell types following induction by viruses, nucleic acids, glucocorticoid hormones, and small molecules. IFNα binds to its receptor (IFNAR1/IFNAR2) on various cell types to trigger various pathways including JAK/STAT, p38, PKC, and IRS/PI3K. IFNα sensitizes T cells to IL-2 induced proliferation, enhances the cytotoxicity of γδ T cells, and promotion of NK cell cytotoxic activity against leukemic cells. IFNα is used as a biomarker for various immunotherapeutic approaches such as acute phase of a viral infection, juvenile polyarthritis, rheumatoid arthritis, lupus, ancylosing spondylitis, polychondritis, psoriatic arthritis, polymyalgia rheumatic, and scleroderma.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine 1C & Chemokine Panel 1 (16 plex)

Multiplex EPX160-12176 RUO

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Human Cytokine Panel 1C (7 plex)

Multiplex EPX070-10010 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Porcine Cytokine & Chemokine Panel 1 (9 plex)

Multiplex EPX090-60829 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex NHP Cytokine Panel 1b (6 plex)

Multiplex EPX060-40042 RUO

ProcartaPlex Mouse Cytokine Panel 1B (10 plex)

Multiplex EPX100-26091 RUO

Anti-Human IFN-alpha

EBI-1 ELISA, FA BMS160* RUO

anti-human IFN-alpha, Biotin (Not available in the United States)

EBI-10 ELISA BMS1016BT* RUO

anti-human IFN-alpha, FITC (Not available in the United States)

EBI-10 ELISA BMS1016FI* RUO

Human IFN-alpha Instant ELISA

ELISA BMS216INST* RUO

Human IFN-alpha Instant ELISA

ELISA BMS216INSTCE* CE

Human IFN alpha Matched Antibody Pairs

ELISA BMS216MST* RUO

Human IFN-alpha Platinum ELISA

ELISA BMS216CE* CE

Human anti-IFN-alpha Platinum ELISA

ELISA BMS217* RUO

Human IFN-alpha Platinum ELISA

ELISA BMS216* RUO

Mouse IFN alpha Platinum ELISA

ELISA BMS6027* RUO

Platinum ProcartaPlex Human IFN alpha Simplex

Multiplex EPXP010-10216 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents