Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
HLA-DQ is one of the HLA (human leukocyte antigen) molecules belonging to class II of the major histocompatibility protein (MHC) surface proteins. HLA-DQ and the other MHC class II molecules are heterodimeric proteins consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages) and present peptides endocytosed, digested, and loaded onto the proteins prior to their migration to the cell surface. Other human MHC class II molecules are HLA-DP, HLA-DM, HLA-DR, HLA-DOA, and HLA-DOB. HLA-DQ displays significant variability, particularly in the beta subunit within the region that affects the peptides bound and presented by the protein. Different classes of DQ based on similar beta subunits allow for the grouping of these variants into serotypes, which can often be recognized by antibodies raised against these subunits. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
BoLA-DQA; BOLA-DQA1; BOLA-DQA2; BOLA-DQA2 protein; BOLA-DQA3; BOLA-DQA5; BOLA-DQB; CELIAC1; HLA class II antigen; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA-DQB; HLA-DQB1; HLA-DRB1; IDDM1; lymphocyte antigen; major histocompatability complex class II; major histocompatibility complex, class II, DQ alpha 1 precursor; major histocompatibility complex, class II, DQ alpha 2; major histocompatibility complex, class II, DQ alpha 5; major histocompatibility complex, class II, DQ alpha, type 1; major histocompatibility complex, class II, DQ alpha, type 3; major histocompatibility complex, class II, DQ beta; major histocompatibility complex, class II, DQ beta 1; MHC class II antigen; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II antigen precursor; MHC class II DQ beta chain; MHC class II DQA; MHC class II DQA precursor; MHC class II DQA1 precursor; MHC class II DQA2 (BoLA-DQA2); MHC class II DQA2 precursor; MHC class II DQB precursor; MHC class II HLA-DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta; similar to MHC class II DQA2 (BoLA-DQA2); Unknown (protein for MGC:127488); Unknown (protein for MGC:137100)
100 Tests
250 µg
100 µg
100 µg
100 µg
100 Tests
100 µg
100 µg
Searching for an antibody we don't offer? We make custom antibodies for specific targets, species and applications.
More than 18,000 custom antibodies created so far.
Talk to a specialist nowIf an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support