Alias: Hepatocyte Growth Factor, scatter factor
HGF is a paracrine multifunctional growth factor. HGF is produced in the liver as well as human platelets, kidney, serum, placenta, lung and spleen. HGF is a mesenchymally derived heparin-binding glycoprotein that is secreted as a single-chainbiologically inert precursor. HGF is coverted to its biologically active pro-HGF form via proteolytic cleavage in response to various signals such as tissue damage. In its active form, HGF binds to and activates the receptor tyrosine kinase c-Met (HGFR) that is expressed in normal epithelium of almost every tissue as well as other cell types that include melanocytes, endothelial cells, microglial cells, neurons, hematopoietic cells, and a variety of tumor cell lines. Once bound, HGF acts as a mitogen, a motogen, and a morphogen as well as a potent anti-inflammatory agent that is involved in the inflammatory response by intercepting NFκB signaling and subsequently disrupting the expression of NFκB-dependent proinflammatory mediators. HGF is also a potent stimulator of angiogenesis and cancer metastasis through its interaction with c-Met to stimulate chemotaxis and growth of malignant cells. HGF is elevated in serum of liver disease patients, and also in patients with various kinds of cancers.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents