This site will redirect to thermofisher.com on April 7. Get details >


HGF

Alias: Hepatocyte Growth Factor, scatter factor

HGF is a paracrine multifunctional growth factor. HGF is produced in the liver as well as human platelets, kidney, serum, placenta, lung and spleen. HGF is a mesenchymally derived heparin-binding glycoprotein that is secreted as a single-chainbiologically inert precursor. HGF is coverted to its biologically active pro-HGF form via proteolytic cleavage in response to various signals such as tissue damage. In its active form, HGF binds to and activates the receptor tyrosine kinase c-Met (HGFR) that is expressed in normal epithelium of almost every tissue as well as other cell types that include melanocytes, endothelial cells, microglial cells, neurons, hematopoietic cells, and a variety of tumor cell lines. Once bound, HGF acts as a mitogen, a motogen, and a morphogen as well as a potent anti-inflammatory agent that is involved in the inflammatory response by intercepting NFκB signaling and subsequently disrupting the expression of NFκB-dependent proinflammatory mediators. HGF is also a potent stimulator of angiogenesis and cancer metastasis through its interaction with c-Met to stimulate chemotaxis and growth of malignant cells. HGF is elevated in serum of liver disease patients, and also in patients with various kinds of cancers.

Suggest a new product or place a custom order.

9 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Growth Factor Panel (11plex)

Multiplex EPX110-12170 RUO

Human HGF Instant ELISA

ELISA BMS2069INST* RUO

Platinum ProcartaPlex Human HGF Simplex

Multiplex EPXP010-12069 RUO

ProcartaPlex Human HGF Simplex

Multiplex EPX01A-12069 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

9 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents