HER-2 is useful in identifying cancer cells with increased aggressiveness. Soluble p97-115 HER-2 (the soluble circulating fragment of p185 HER-2) protein levels in serum can be used as a diagnostic tool for monitoring the extent of tumor spread, postoperative relapse and/or metastatic risk for different cancers. 32% of ovarian carcinomas overexpress the HER-2 oncoprotein. Survival is significantly worse compared with cases of normal HER-2 protein expression. Additionally, tumors with high HER-2 protein expression are significantly less likely to responsd to primary therapy. A correlation between HER-2 expression and clinical outcome has been also demonstrated for head and neck, salivary gland and placental carcinomas.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents