This site will redirect to thermofisher.com on April 7. Get details >


Granzyme B

Also: GZMB

Granzymes are exogenous serine proteinases released from cytoplasmic granules of cytotoxic lymphocytes (CTLs) and NK cells. The name “granzymes” is derived from: granules + enzymes. Upon binding of the CTL to a target cell, the contents of the granules are released in the intercellular space where perforin perforates the target cell membrane by forming transmembrane pores. Through these pores, granzymes enter the cytosol of the target cell to intiate the apoptotic pathway. Granzyme B has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. Granzyme B activates the intracellular cascade of caspases finally resulting in the killing of the target cells.

Suggest a new product or place a custom order.

19 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

Anti-Mouse Granzyme B Biotin

16G6 FC, IHC, IHC-P, WB 13-8822 RUO

Anti-Mouse Granzyme B Purified

16G6 ELISA, IHC, IHC-P, WB 14-8822 RUO

Anti-Mouse Granzyme B Biotin

eBioLUEE ELISA 13-8821 RUO

Human Granzyme B Platinum ELISA

ELISA BMS2027* RUO

Mouse Granzyme B Platinum ELISA

ELISA BMS6029* RUO

Mouse Granzyme B ELISA Ready-SET-Go!®

ELISA 88-8022 RUO

Anti-Mouse Granzyme B FITC

NGZB FC 11-8898 RUO

Anti-Human Granzyme B PE

GB11 FC 12-8899 RUO

Anti-Mouse Granzyme B eFluor® 660

NGZB FC 50-8898 RUO

Anti-Mouse Granzyme B eFluor® 450

NGZB FC 48-8898 RUO

Anti-Mouse Granzyme B PE

NGZB FC 12-8898 RUO

Anti-Mouse Granzyme B PE-Cyanine7

NGZB FC 25-8898 RUO

Anti-Mouse Granzyme B PE-eFluor® 610

NGZB FC 61-8898 RUO

Anti-Mouse Granzyme B PerCP-eFluor® 710

NGZB FC 46-8898 RUO

ProcartaPlex NHP Granzyme B Simplex

Multiplex EPX01A-42027 RUO

ProcartaPlex Human Granzyme B Simplex

Multiplex EPX01A-12027 RUO

Anti-Human Granzyme B eFluor® 615

496B ICC, IHC 42-8889 RUO

Anti-Human Granzyme B Purified

496B ICC, IHC 14-8889 RUO

Mouse Granzyme B Single-Use ELISA RSG Standard

ELISA 39-8237 RUO

19 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents