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Granzyme A

Also: GZMA

Granzymes are exogenous serine proteinases released from cytoplasmic granules of cytotoxic lymphocytes (CTLs) and NK cells. The name “granzymes” is derived from: granules + enzymes. Upon binding of the CTL to a target cell, the contents of the granules are released in the intercellular space where perforin perforates the target cell membrane by forming transmembrane pores. Through these pores, granzymes enter the cytosol of the target cell to intiate the apoptotic pathway. Not all granzymes enter the target cell as some are present in the peripheral blood and other biological fluids. Though detectable amounts of granzymes have been found to circulate in healthy volunteers, increased levels serve as biomarkers for many diseases including patients with systemic viral infections such as EBV, HIV, CMV, hepatitis A and Dengue fever. Additionally, lymphomas and carcinomas show a high percentage of Granzyme B positive CTLs in glands of patients suffering from Hodgkin’s disease which correlates with a poor prognosis. In rheumatoid arthritis, soluble Granzyme A and B levels are increased in synovial fluid; significantly higher than levels in patients with osteoarthritis. In transplantation, Granzymes are likely involved in the acute rejection of kidney-transplants, as infiltrating lymphocytes in the rejected kidney strongly express granzymes.

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8 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

Anti-Human Granzyme A eFluor® 660

CB9 FC 50-9177 RUO

Anti-Human Granzyme A PE

CB9 FC 12-9177 RUO

Anti-Human Granzyme A PE-Cyanine7

CB9 FC 25-9177 RUO

Anti-Mouse Granzyme A APC

GzA-3G8.5 FC 17-5831 RUO

Anti-Mouse Granzyme A eFluor® 450

GzA-3G8.5 FC 48-5831 RUO

Anti-Mouse Granzyme A PE

GzA-3G8.5 FC 12-5831 RUO

Anti-Mouse Granzyme A PE-Cyanine7

GzA-3G8.5 FC 25-5831 RUO

Anti-Mouse Granzyme A PerCP-eFluor® 710

GzA-3G8.5 FC 46-5831 RUO

8 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents