Alias: GITRL, TNFSF18, Tumor necrosis factor ligand superfamily member 18
GITRL is a type II transmembrane protein of the TNF superfamily and is expressed by endothelial cells and peripheral blood monocytes. GITRL binds to GITR/AITR, belonging to the Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naïve mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (TReg) and by CD25+ CD4+ CD8- thymocytes. Stimulation with GITRL abrogates TReg cell-mediated suppression. The removal of GITR-expressing TReg cells or the administration of GITR antibody (DTA-1) resulted in organ specific autoimmune disease. Interaction of GITR, expressed by CD4+CD25+ TReg cells, with GITRL is important for cross-talk between T lymphocytes and endothelial cells.
|eBioYGL386 (YGL 386, YGL-386)||FC||12-5854||RUO|
* = Please click on product link to see all available sizes and pricing.
FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents