G-CSF

Alias: Granulocyte Colony-Stimulating Factor, CSF3

G-CSF is a member of the IL-6 cytokine family. G-CSF is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, and osteoblasts in response to infection and inflammatory mediators such as IL-1β, IL-17, TNFα, and LPS, as well as various transformed cells such as carcinoma cells and myeloblastic leukemia cells. G-CSF has been shown to have specific effects on the proliferation, differentiation, and activation of hematopoietic cells. G-CSF binding activates the JAK/STAT signaling pathway that results in the activation and mobilization of granulocytic precursors from the bone marrow and supports the proliferation, activation, and differentiation of neutrophils in the blood. Clinically, the use of G-CSF has been approved for several therapeutical applications including the treatment of neonatal infections, therapy of acute myocardial infarction, therapy in chronic autoimmune neutropenia, treatment of acute myeloid leukemias, Sweet’s syndrome, and AIDS. G-CSF has further been shown to be a marker protein for different carcinomas such as bladder cancer. (34, 75)

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Name	Clone	Application	Cat. No.	Reg.
Anti-Mouse G-CSF Functional Grade Purified	9B4CSF	FA	16-7353	RUO
Anti-Mouse G-CSF eFluor® 660 (Alexa Fluor® 647 Replacement)	9B4CSF	FC	50-7353	RUO
Human Inflammation 20plex Ready-to-Use FlowCytomix Multiplex		Multiplex	BMS819FFRTU*	RUO
ProcartaPlex Mouse G-CSF/CSF-3 Simplex		Multiplex	EPX010-26034	RUO
SAFE™ Human G-CSF Recombinant Animal Free Protein		FA	68-8788	RUO
Recombinant Human G-CSF			BMS322*	RUO
Recombinant Mouse G-CSF			BMS323*	RUO
Human G-CSF Recombinant Protein Carrier-Free		FA	34-8523	RUO
Human G-CSF Recombinant Protein		FA	14-8523	RUO
Human G-CSF FlowCytomix Simplex		Multiplex	BMS82001FF*	RUO
Human G-CSF Instant ELISA		ELISA	BMS2001INST*	RUO
Human G-CSF Instant ELISA		ELISA	BMS2001INSTCE*	CE
Anti-Human G-CSF PE	8F5CSF	FC	12-7351	RUO
Anti-Human G-CSF eFluor® 660	8F5CSF	FC	50-7351	RUO
Anti-Human G-CSF Functional Grade Purified	4A4RC	FA	16-7338	RUO
Human Chemokine 6plex FlowCytomix Multiplex		Multiplex	BMS813FF*	RUO

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents