Alias: FGF-8b, Fibroblast Growth Factor 8
FGF-8 is a member of the highly conserved fibroblast growth factor family of heparin-binding proteins that affect the proliferation, differentiation, mobility, and survival of several cell types, including fibroblasts, osteoblasts, smooth muscle cells, and neuroblasts. Like FGF-2, it binds to FGFR 1-4 and requires the binding of heparin sulfate proteoglycan to fully activate these receptors. FGF-8 exists in eight isoforms designated a-h, although only a, b, e, and f are present in humans. FGF-8 is active mainly during embryonic development and functions to promote skeletal growth and limb bud formation. Expression in adults is limited to tissues involved in spermatogenesis and oogenesis as well as some cancers. It is the first member of the family to have been identified in breast cancer and is believed to contribute to its progression in an autocrine manner.