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FGF-2 is a member of the FGF family of growth factors that exists in several isoforms, and although they are equally active, only the 18 kDa form is secreted while the 23 kDa form localizes to the nucleus. FGF-2 is a ligand for four common tyrosine kinase receptors, FGFR 1-4, and require the binding of a second surface protein, the ubiquitously expressed heparin sulfate proteoglycan, in order to fully activate these receptors. FGF family members affect the proliferation, differentiation, mobility, and survival of several cell types, including fibroblasts, osteoblasts, smooth muscle cells, and neuroblasts. FGF-2 expression has been detected in several cell types, including fibroblasts, macrophages, endothelial cells, epithelial cells, and neurons. FGF-2 is particularly important in embryonic development as triggers of neurogenesis, angiogenesis, and neovascularization and has most recently been studied for its ability to maintain the proliferation of embryonic stem cell cultures in an undifferentiated state. Some members of the family, including FGF-2, remain active during adulthood and play a role in bone formation and tissue repair. FGF family members are also implicated in many types of cancer and may contribute to tumor vascularization.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

SAFE™ Human FGF basic Recombinant Animal Free Protein

FA 68-8785 RUO

ProcartaPlex NHP FGF-2 Simplex

Multiplex EPX01A-42074 RUO

ProcartaPlex Human FGF-2 Simplex

Multiplex EPX01A-12074 RUO

ProcartaPlex Human Growth Factor Panel (11plex)

Multiplex EPX110-12170 RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

7 Item(s)

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25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents