This site will redirect to thermofisher.com on April 7. Get details >


EGF

Alias: Epidermal Growth Factor

EGF stimulates the growth and differentiation of many cells types and plays a role in the development and regeneration of various tissues by binding to the receptor tyrosine kinase EGFR that results in receptor dimerization, autophosphorylation, and subsequent signaling cascade down many pathways that include the MAPK and AKT pathways. EGF, like many other members of its family, is synthesized as type I transmembrane protein of 130 kDa with an N-terminal extension called the EGF module, a short juxtamembrane stalk, a hydrophobic transmembrane domain, and a cytoplasmic tail. As a result of proteolytic cleavage, the soluble EGF is released into the extracellular space. Once released, it stimulates the proliferation of epidermal and epithelial cells such as fibroblasts and kidney epithelial cells, endothelial cells, as well as embryonic cells. Blocking the release of EGF receptor ligands inhibits growth and migration in several EGF receptor-dependent cell lines and greatly retards wound re-epithelialization due to impaired keratinocyte migration. Overexpression of one or more receptors and/or ligands is a feature of the majority of human carcinomas and epithelial cancers.

Suggest a new product or place a custom order.

8 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

Human EGF Instant ELISA

ELISA BMS2070INST* RUO

ProcartaPlex Human EGF Simplex

Multiplex EPX01A-12070 RUO

Recombinant Human EGF

BMS320* RUO

Mouse EGF Recombinant Protein (Discontinued)

FA 14-8984 RUO

ProcartaPlex Human Growth Factor Panel (11plex)

Multiplex EPX110-12170 RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

8 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents