Alias: Epidermal Growth Factor
EGF stimulates the growth and differentiation of many cells types and plays a role in the development and regeneration of various tissues by binding to the receptor tyrosine kinase EGFR that results in receptor dimerization, autophosphorylation, and subsequent signaling cascade down many pathways that include the MAPK and AKT pathways. EGF, like many other members of its family, is synthesized as type I transmembrane protein of 130 kDa with an N-terminal extension called the EGF module, a short juxtamembrane stalk, a hydrophobic transmembrane domain, and a cytoplasmic tail. As a result of proteolytic cleavage, the soluble EGF is released into the extracellular space. Once released, it stimulates the proliferation of epidermal and epithelial cells such as fibroblasts and kidney epithelial cells, endothelial cells, as well as embryonic cells. Blocking the release of EGF receptor ligands inhibits growth and migration in several EGF receptor-dependent cell lines and greatly retards wound re-epithelialization due to impaired keratinocyte migration. Overexpression of one or more receptors and/or ligands is a feature of the majority of human carcinomas and epithelial cancers.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents