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EBI3 (IL-27 Subunit)

EBI3 is a component of two of the four members of the IL-12 family. EBI3 was first found to heterodimerize with p28 (IL-30) to form IL-27 that is secreted by antigen-presenting cells in response to pro-inflammatory stimuli. IL-27 has been shown to have both pro-inflammatory and anti-inflammatory effects. It influences the commitment of CD4+ T-cells toward the TH1 lineage by inducing the expression of the T-bet transcription factor and the upregulation of IL-12R beta 2. Its anti-inflammatory functions include the suppression of TH2 and TH17 proliferation and differentiation. Just as with p35 above, EBI3 was also found to dimerize with another IL-12 family member to form IL-35.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse EBI3 (IL-27 subunit) Purified

DNT27 WB 14-7273 RUO

Anti-Human IL-27 EBI3 APC

ebic6 FC 17-7358 RUO

Anti-Human IL-27 EBI3 PE

ebic6 FC 12-7358 RUO

Anti-Human IL-27 EBI3 PerCP-eFluor® 710

ebic6 FC 46-7358 RUO

Human IL-27 Platinum ELISA


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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents