Alias: monokine induced by IFNγ, Chemokine (C-X-C motif) ligand 9
MIG belongs to the CXC subfamily of chemokines. Induced by IFNγ and secreted mostly by macrophages, CXCL9 functions to recruit leukocytes to sites of infection and inflammation by its biding to a receptor that is selectively expressed in activated T-lymphocytes and therefore is a critical mediator of T-lymphocyte migration in T-cell dependent immune responses. Like IP-10, MIG binds to the chemokine receptor CXCR3 in TH1 immune reactions and exhibits inhibitory functions in neovascularization. Additionally, MIG is an inhibitor for hematopoietic progenitor cells and shows anti-tumor effects. Furthermore, there are indications that MIG plays an important role in mediating cell recruitment and activation necessary for inflammation and the repair of tissue damage (e.g. in liver diseases).
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents