CXCL10 (IP-10)

Alias: C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein

IP-10 is a member of the CXC subfamily of chemokines expressed by monocytes. IP-10 plays a pivotal role in the immune system development. IP-10 is induced in monocytes, fibroblasts, and endothelial cells by IFNγ. IP-10 is also known to be induced by LPS, IL-1β, TNFα, IL-12, and viral infection. Its pleiotropic functions include the stimulation of monocytes, natural killer, and T-cell migration, as well as the regulation of T-cell and bone marrow progenitor maturation. IP-10 is also involved in the modulation of adhesion molecule expression and inhibition of angiogenesis. IP-10 is also a chemoattractant for CXCR3+ T cells, which play an important role in TH 1-type inflammatory diseases, as well as several endocrine-related autoimmune diseases such as Hashimoto’s thyroiditis.