Alias: C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein
IP-10 is a member of the CXC subfamily of chemokines expressed by monocytes. IP-10 plays a pivotal role in the immune system development. IP-10 is induced in monocytes, fibroblasts, and endothelial cells by IFNγ. IP-10 is also known to be induced by LPS, IL-1β, TNFα, IL-12, and viral infection. Its pleiotropic functions include the stimulation of monocytes, natural killer, and T-cell migration, as well as the regulation of T-cell and bone marrow progenitor maturation. IP-10 is also involved in the modulation of adhesion molecule expression and inhibition of angiogenesis. IP-10 is also a chemoattractant for CXCR3+ T cells, which play an important role in TH 1-type inflammatory diseases, as well as several endocrine-related autoimmune diseases such as Hashimoto’s thyroiditis.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents