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CXCL1 (GRO alpha)

Alias: GROα, Growth-regulated alpha protein

GROα (CXCL1) is a pro-inflammatory CXC chemokine first identified by its constitutive overexpression in some tumors. It is closely related to GROβ (CXCL2) and GROγ (CXCL3) with which it shares 90% and 86% sequence homology, respectively. These proteins, along with IL-8 (CXCL8), are critical for neutrophil mobilization and degranulation, as well as vascular permeabilization and angiogenesis. GROα is secreted by monocytes, epithelial cells, and fibroblasts in response to pro-inflammatory stimuli such as LPS, IL-1β, and TNFα. Signaling occurs through the GPCR CXCR2, which is shared with both GROβ and GROγ. Overexpression of GROα has been observed in many malignant tumors, where it contributes to tumor vascularization and metastasis.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Chemokine Panel 1 (9 plex)

Multiplex EPX090-12187 RUO

ProcartaPlex Mouse Chemokine Panel 1 (9 plex)

Multiplex EPX090-20821 RUO

ProcartaPlex Rat Chemokine Panel (8 plex)

Multiplex EPX080-30121 RUO

Anti-Human CXCL1 (GRO alpha) eFluor® 660

KTYFLF FC 50-7515 RUO

ProcartaPlex Human Cytokine 1C & Chemokine Panel 1 (16 plex)

Multiplex EPX160-12176 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse Essential Panel 2 (8 plex)

Multiplex EPX080-20832 RUO

Human GRO alpha (CXCL1) Platinum ELISA

ELISA BMS2122* RUO

Platinum ProcartaPlex Human GRO alpha (KC/CXCL1) Simplex

Multiplex EPXP010-12122 RUO

ProcartaPlex Rat GRO alpha (KC/CXCL1) Simplex

Multiplex EPX01A-36031 RUO

ProcartaPlex Human GRO alpha (KC/CXCL1) Simplex

Multiplex EPX01A-12122 RUO

ProcartaPlex Mouse GRO alpha (KC/CXCL1) Simplex

Multiplex EPX01A-26031 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

ProcartaPlex Mouse 36plex Control Set

Multiplex EPX360-26092* RUO

ProcartaPlex Human Th1/Th2 & Chemokine Panel 1 (20 plex)

Multiplex EPX200-12173 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents