CXCL1 (GRO alpha)
Alias: GROα, Growth-regulated alpha protein
GROα (CXCL1) is a pro-inflammatory CXC chemokine first identified by its constitutive overexpression in some tumors. It is closely related to GROβ (CXCL2) and GROγ (CXCL3) with which it shares 90% and 86% sequence homology, respectively. These proteins, along with IL-8 (CXCL8), are critical for neutrophil mobilization and degranulation, as well as vascular permeabilization and angiogenesis. GROα is secreted by monocytes, epithelial cells, and fibroblasts in response to pro-inflammatory stimuli such as LPS, IL-1β, and TNFα. Signaling occurs through the GPCR CXCR2, which is shared with both GROβ and GROγ. Overexpression of GROα has been observed in many malignant tumors, where it contributes to tumor vascularization and metastasis.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents