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CD257 (BAFF, BLyS)

Alias: BAFF, BLyS, Tumor necrosis factor ligand superfamily member 13B

BAFF (B cell activating factor belonging to the TNF family) is a TNF family member. BAFF/BLyS is a B lymphocyte stimulatory molecule that induces B cell proliferation and immunoglobulin secretion. Like APRIL, it is heterotrimeric transmembrane protein that is proteolytically processed to produce a soluble cytokine. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain that is cleaved to produce the soluble form detectable in serum. Both BAFF and APRIL bind to the receptors BCMA and TACI, while only BAFF binds to the BAFF Receptor (BAFFR). Both BAFF and APRIL are upregulated by type I interferons, IFNγ, IL-10, G-CSF, and certain TLRs. BAFF functions as a key regulator of B-cell homeostasis and increased levels of BAFF in human sera have been found in primary biliary cirrhosis, autoimmune diabetes, rheumatic diseases, and Sjogren’s syndrome.

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9 Item(s)

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Name Clone Application Cat. No. Reg.  

Human BAFF Instant ELISA

ELISA BMS2007INST* RUO

ProcartaPlex Human BAFF Simplex

Multiplex EPX01A-12007 RUO

ProcartaPlex Mouse BAFF Simplex

Multiplex EPX01A-26096 RUO

Anti-Human CD257 (BAFF, BLyS) APC

1D6 FC 17-9017 RUO

Anti-Human CD257 (BAFF, BLyS) FITC

1D6 FC 11-9017 RUO

Anti-Human CD257 (BAFF, BLyS) PE

1D6 FC 12-9017 RUO

Anti-Human CD257 (BAFF, BLyS) Purified

1D6 FC, IHC, WB 14-9017 RUO

Human CD257 (BAFF, BLyS) Recombinant Protein

FA 14-8943 RUO

ProcartaPlex Human TNF Superfamily Panel (15 plex)

Multiplex EPX150-15801 RUO

9 Item(s)

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25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents