CD185 (CXCR5) is one of the defining cell surface markers of T follicular helper (Tfh) cells. CXCR5 is the receptor for CXCL13. It’s up regulation in concert with increased levels of CXCL13, along with the reduction of CCR7 on the Tfh cell, trigger the homing of Tfh cells to the CXCL13-rich B follicles where they are essential in the development of antigen-specific effector and memory B cell responses.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents