CD157 is an ectoenzyme belonging to the ADP-ribosyl cyclase family and is a member of the growing group of leukocyte surface markers known to act as both a receptor and enzyme. CD157, also known as bone marrow stromal cell antigen (BST-1) or Cyclic ADP-ribose hydrolase 2, is a 45 kDa glycosylphosphatidylinositol-anchored molecule facilitating pre-B cell stimulation and proliferation. It functions similarly to CD38 and is implicated in the metabolism of NAD+, an activity which may be involved in regulating intracellular Ca2+ levels.
CD157 is expressed on monocytes and macrophages and is thought to act independently as an enzyme co-receptor, binding its putative ligand thereby initiating a signal transduction cascade, resulting in the phosphorylation of cytoplasmic proteins including focal adhesion kinase (FAK). It is thought to be involved in rheumatoid arthritis due to enhanced expression in RA-derived bone marrow stromal lines.
|eBioSY11B5 (SY11B5)||FC, IHC, IP, WB||14-1579||RUO|
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents