Alias: Monocyte Chemoattractant Protein 3, C-C motif chemokine 7
MCP-3 belongs to the CC-family of chemokines and is one of the most pluripotent chemokine that activates all types of leukocytes acting as a ligand for at least four different chemokine receptors. The natural protein is heterogeneous due to post-translational modifications glycosylation and NH2-terminal processing. In addition to it chemoattractant properties, MCP-3 may also affect HIV-1 infection via inhibiting the binding of HIV envelope to CCR5, the co-receptor to HIV. Like for MCP-1, MCP-3 has also been implicated in Multiple Sclerosis, allergic reactions and viral infections. Furthermore the presence of MCP-3 has been described in several lung diseases, pathologies of the gastro-intestinal system and vernal keratoconjunctivitis.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents