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CCL3 (MIP-1 alpha)

Alias: MIP-1α, Macrophage Inflammatory Protein 1-alpha, C-C motif chemokine 3

MIP-1α, along with the closely related MIP-1β (CCL4), is a member of the CC-subfamily of chemokines. These proteins play critical roles in the recruitment of leukocytes to the site of inflammation and signal through CCR1, CCR4, and CCR5. MIP-1α and MIP-1β are involved in the response to cellular and humoral immune response. MIP-1α stimulates strong antigen specific responses, while MIP-1β promotes antibody responses. While both CCL3 and CCL4 are both chemoattractant for monocytes, macrophages, and dendritic cells, they differ in their responses with T cells. While MIP-1α preferentially attracts CD8+ T cells, CD4+ T cells are more responsive to MIP-1β. In addition to its chemotactic and co-activator functions, MIP-1α also induces inflammatory cytokine secretion, mast cell degranulation, and NK cell activation. MIP-1 protein expression levels have been shown to be important regarding numerous diseases such as multiple myeloma, asthmatic disorders, EAE, HIV, and sepsis.

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20 Item(s)

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Name Clone Application Cat. No. Reg.  

Anti-Human CCL3 (MIP-1 alpha) FITC

CR3M FC 11-9706 RUO

Anti-Human CCL3 (MIP-1 alpha) PE

CR3M FC 12-9706 RUO

Human CCL3 (MIP-1 alpha) Single-Use ELISA RSG Standard

ELISA 39-8238 RUO

Anti-Mouse CCL3 (MIP-1 alpha) eFluor® 660

DNT3CC FC 50-7532 RUO

Anti-Mouse CCL3 (MIP-1 alpha) PE

DNT3CC FC 12-7532 RUO

Anti-Mouse CCL3 (MIP-1 alpha) PerCP-eFluor® 710

DNT3CC FC 46-7532 RUO

Mouse CCL3 (MIP-1 alpha) Recombinant Protein (To be Discontinued)

FA 14-8000 RUO

Human CCL3 (MIP-1 alpha) ELISA Ready-SET-Go!

ELISA 88-7035 RUO

ProcartaPlex Human Chemokine Panel 1 (9 plex)

Multiplex EPX090-12187 RUO

ProcartaPlex Rat Chemokine Panel (8 plex)

Multiplex EPX080-30121 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Inflammation Panel (20 plex)

Multiplex EPX200-12185 RUO

Mouse MIP-1 alpha (CCL3) ELISA Ready-SET-Go!

ELISA 88-56013 RUO

ProcartaPlex Rat MIP-1 alpha (CCL3) Simplex

Multiplex EPX01A-36013 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

20 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents