Alias: Monocyte Chemotactic Protein 1, C-C motif chemokine 2
MCP-1 is a member of the ß (CC) subfamily of chemokines. MCP-1 is mainly expressed by macrophages in response to a wide range of cytokines that include IL-1β, IL-6, and TNFα, but can also be produced by a variety of other cells and tissues, such as fibroblasts, endothelial cells, or certain tumor cells. MCP-1 functions as a chemoattractant protein for monocytes, T lymphocytes, and NK cells where it helps to regulate their adhesion molecule and cytokine expression patterns. MCP-1 has also been shown to activate monocytes to be cytostatic for some human tumor cell lines and attracting, activating, and inducing basophils to release histamine. Elevated levels of MCP-1 have also been found in connection with inflammation, Alzheimer’s disease (AD), myocardial ischemia, and viral infections.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents