Alias: Monocyte Chemotactic Protein 1, C-C motif chemokine 2
MCP-1 is a member of the ß (CC) subfamily of chemokines. MCP-1 is mainly expressed by macrophages in response to a wide range of cytokines that include IL-1β, IL-6, and TNFα, but can also be produced by a variety of other cells and tissues, such as fibroblasts, endothelial cells, or certain tumor cells. MCP-1 functions as a chemoattractant protein for monocytes, T lymphocytes, and NK cells where it helps to regulate their adhesion molecule and cytokine expression patterns. MCP-1 has also been shown to activate monocytes to be cytostatic for some human tumor cell lines and attracting, activating, and inducing basophils to release histamine. Elevated levels of MCP-1 have also been found in connection with inflammation, Alzheimer’s disease (AD), myocardial ischemia, and viral infections.
|2H5||FC, ELISA, IHC, IHC-F, WB||14-7096||RUO|
|5D3-F7||FC, ELISA, IHC, IHC-P, IP||14-7099||RUO|
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents