Alias: C-C motif chemokine 12, Monocyte Chemoattractant Protein 5
MCP-5 is a CC chemokine family member. Constitutive expression of MCP-5 has been detected predominantly in lymph nodes, and its expression is markedly induced in macrophages. Functionally, MCP-5 acts as a strong chemoattractant for monocytes and macrophages where it is involved in allergic inflammation and the host response to pathogens. MCP-5 is only weakly active on eosinophils and inactive on neutrophils though. Once expressed, MCP-5 induces a calcium flux in peripheral blood mononuclear cells.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents