iPS Cells on Demand
B18R is a virally-encoded protein that acts as a decoy receptor for Type 1 Interferons. Recently identified by Warren et al.*, B18R enables increased cell viability during RNA transfection protocols designed to convert human somatic donor cells into iPSCs via direct delivery of synthetic mRNA's.
Control Reprogramming with B18R
- Enables highly efficient reprogramming of somatic cells to pluripotency, allowing for re-directed differentiation toward a desired lineage.
- Removed the risk of genomic integration and insertional mutagenesis inherent to DNA-bases methodologies.
- Eliminates the need for virus-based approaches.