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B18R

iPS Cells on Demand

B18R is a virally-encoded protein that acts as a decoy receptor for Type 1 Interferons.  Recently identified by Warren et al.*, B18R enables increased cell viability during RNA transfection protocols designed to convert human somatic donor cells into iPSCs via direct delivery of synthetic mRNA's.

Control Reprogramming with B18R

  • Enables highly efficient reprogramming of somatic cells to pluripotency, allowing for re-directed differentiation toward a desired lineage.
  • Removed the risk of genomic integration and insertional mutagenesis inherent to DNA-bases methodologies.
  • Eliminates the need for virus-based approaches.

Learn more about Induced Pluripotent Stem Cell (iPS) reprogramming with mRNA and B18R

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Name Clone Application Cat. No. Reg.  

B18R Recombinant Protein

FA 14-8185 RUO

B18R Recombinant Protein Carrier-Free

FA 34-8185 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents