Alias: CD256, TNFSF13, Tumor necrosis factor ligand superfamily member 1
APRIL (A Proliferation-Inducing Ligand) is a member of the tumor necrosis factor family and is closely related to BAFF, both of which activate their receptors and transmit survival and growth signals to B cells. In its membrane bound form, APRIL is a homotrimeric type II transmembrane protein. It is proteolytically processed to produce a soluble cytokine. In their soluble forms, both APRIL and BAFF bind to the receptors BCMA and TACI, respectively. APRIL appears to have direct connections to various diseases that include cancer and arthritis with higher levels of APRIL expression seen in various tumors and APRIL-transfected cells showing an increased rate of tumor growth. Concerning arthritis, local production of APRIL is found in the arthritic joints of patients with inflammatory arthritis.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents