Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic effects of a diverse group of environmental contaminants, naturally occurring compounds, as well as compounds generated through normal cellular metabolism. Recent studies have uncovered AHR as a powerful modulator of immune and inflammatory responses and a promising target for pharmacological treatment of certain autoimmune and inflammatory diseases.
AHR acts as a critical physiological regulator in both the adaptive and innate immune systems, with its expression occurring in several immune cells including Th17 cells, Treg subsets, dendritic cells and innate lymphoid cells. Residing in the cytosol in its inactive form, AHR transcriptional activity requires interaction with an exogenous or endogenous ligand to undergo conformational change and translocate to the nucleus.
- Important role in Th17 differentiation with control over IL-21 and IL-22 expression
- Promotes Th17 cell development and therefore important in maintaining gut immunity
- Modulates development of regulatory T cells (Tregs) through multiple mechanisms
|FF3399||FC, ICC, IHC, IHC-P, WB||14-9854||RUO|
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents