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AHR

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic effects of a diverse group of environmental contaminants, naturally occurring compounds, as well as compounds generated through normal cellular metabolism. Recent studies have uncovered AHR as a powerful modulator of immune and inflammatory responses and a promising target for pharmacological treatment of certain autoimmune and inflammatory diseases.

AHR acts as a critical physiological regulator in both the adaptive and innate immune systems, with its expression occurring in several immune cells including Th17 cells, Treg subsets, dendritic cells and innate lymphoid cells. Residing in the cytosol in its inactive form, AHR transcriptional activity requires interaction with an exogenous or endogenous ligand to undergo conformational change and translocate to the nucleus.

  • Important role in Th17 differentiation with control over IL-21 and IL-22 expression
  • Promotes Th17 cell development and therefore important in maintaining gut immunity
  • Modulates development of regulatory T cells (Tregs) through multiple mechanisms

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9 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

Anti-Mouse AHR Alexa Fluor® 488

4MEJJ FC 53-5925 RUO

Anti-Mouse AHR eFluor® 660

4MEJJ FC 50-5925 RUO

Anti-Mouse AHR PE

4MEJJ FC 12-5925 RUO

Anti-Mouse AHR PE-Cyanine7

4MEJJ FC 25-5925 RUO

Anti-Human AHR eFluor® 660

FF3399 FC 50-9854 RUO

Anti-Human AHR PE

FF3399 FC 12-9854 RUO

Anti-Human AHR PE-Cyanine7

FF3399 FC 25-9854 RUO

Anti-Human AHR PerCP-eFluor® 710

FF3399 FC 46-9854 RUO

Anti-Human AHR Purified

FF3399 FC, ICC, IHC, IHC-P, WB 14-9854 RUO

9 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents